In the 2021 NCAA Tournament, Juzang joined Miller and Kareem Abdul-Jabbar, known in college as Lew Alcindor, to become the third player in UCLA history to score at least 20 points in their first two NCAA Tournament games. He scored 28 points in a 51–49 win over No. 1 seed Michigan, as UCLA advanced to their first Final Four since 2008. Eighteen of his points came in the first half, which included a run where he scored 12 consecutive for the Bruins. He became the first player to score at least half of his team's points in a regional finals win since Oscar Robertson in 1960. He was named the most outstanding player of the tournament's East Region. Juzang scored 29 points in the national semifinal against 1-seed Gonzaga, including a basket to tie the game with 3. 3 seconds remaining in overtime, but the Bulldogs' Jalen Suggs made a 40-foot (12 m) buzzer beater to win 93–90 over the Bruins. Named to the 2021 All-Tournament Team, Juzang scored 137 total points in the tournament, the second most by a UCLA player in NCAA Tournament history behind Gail Goodrich's 140 points in 1965. He scored 20 or more points four times in the tournament for a total of eight during the season.